Hydrogen Peroxide → 4-[2-(4-Fluoro-phenyl)-1,1-dimethoxy-ethyl]-pyridine 1-oxide

HRID 659949

반응식

HRID 659949 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)([O:12][CH3:13])[O:10][CH3:11])=[CH:4][CH:3]=1.[OH:20]O>ClCCl.C[Re](=O)(=O)=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:14]2[CH:15]=[CH:16][N+:17]([O-:20])=[CH:18][CH:19]=2)([O:10][CH3:11])[O:12][CH3:13])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 784Hydrogen PeroxideHCID 149562264-[2-(4-Fluoro-phenyl)-1,1-dimethoxy-ethyl]-pyridine

생성물 1

HCID 684293414-[2-(4-Fluoro-phenyl)-1,1-dimethoxy-ethyl]-pyridine 1-oxide

시약·촉매·용매 2

HCID 178477782HCID 178477782, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

55 g (0.21 mole) of 4-[2-(4-Fluoro-phenyl)-1,1-dimethoxy-ethyl]-pyridine and 445 mg of methyltrioxorhenium are dissolved in 250 mL of dichloromethane. 112 mL of commercial hydrogen peroxide solution is added to the reaction mixture which is further stirred over night at room temperature. The reaction mixture is then decanted and the organic phase is washed with sodium hydrogen sulfate and water and dried over magnesium sulfate. After concentration, 33 g of 4-[2-(4-Fluoro-phenyl)-1,1-dimethoxy-ethyl]-pyridine 1-oxide is obtained as a green oil.

후처리

  1. customThe reaction mixture is then decanted
  2. washthe organic phase is washed with sodium hydrogen sulfate and water
  3. dry with materialdried over magnesium sulfate
  4. concentrationAfter concentration

출처 및 근거

ORD 기록
ord-fae9c6c33f6a453e8bf832c89648a41c
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084395B2

연결된 노트

불러오는 중…