Sodium Carbonate → 5-Oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid

HRID 65999노트

반응식

HRID 65999 반응식
[O:1]=[C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[N:7][C:6]=2[N:5]([CH2:12][CH3:13])[CH:4]=[C:3]1[C:14]([O:16]CC)=[O:15].C([O-])([O-])=O.[Na+].[Na+]>C(O)(=O)C>[O:1]=[C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[N:7][C:6]=2[N:5]([CH2:12][CH3:13])[CH:4]=[C:3]1[C:14]([OH:16])=[O:15]

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 227568395-Oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine

생성물 1

HCID 227568245-Oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

0.6 g. of this ester and 10 cm3 of a 10% solution of Na2CO3 are heated under reflux for 20 minutes. After cooling, the solution is acidified by means of acetic acid. The precipitate (0.5 g.) is filtered off and recrystallised from water. 0.2 g. of 5-oxo-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid is obtained, melting point 225° C. (decomposition).

후처리

  1. temperatureunder reflux for 20 minutes
  2. temperatureAfter cooling
  3. filtrationThe precipitate (0.5 g.) is filtered off
  4. customrecrystallised from water

출처 및 근거

ORD 기록
ord-ee90deb319b240c99347b3023f21024b
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129737

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