Chlorosuccinimide → 3-chloro-1H-indole-5-carbaldehyde
반응식
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([CH:10]=[O:11])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[Cl:12]N1C(=O)CCC1=O>C(Cl)Cl>[Cl:12][C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[C:6]([CH:10]=[O:11])[CH:5]=2)[NH:1][CH:2]=1참가 물질
4
실험 절차
To a stirred solution of 1H-indole-5-carbaldehyde (0.50 g, 3.44 mmol) in DCM (25 mL) was added N-chlorosuccinimide (0.44 g, 3.27 mmol). After 4 h, the mixture was washed with water (50 mL) and the organic layer was dried and concentrated to obtain the crude residue (0.62 g), which was used without purification. 1H NMR (CDCl3): 10.04 (s, 1H), 8.17-8.15 (m, 1H), 7.79 (dd, J=8.6, 1.5 Hz, 1H), 7.46 (d, J=8.6 Hz, 1), 7.29-7.28 (m,1H).
후처리
- washthe mixture was washed with water (50 mL)
- customthe organic layer was dried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-be7f6b26d82e49818279e3a6257a59ee
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08084466B2
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