3-chloro-1H-indole-5-carbaldehyde → 4-[4-(3-Chloro-4-formyl-indol-1-yl)-butyl]-piperidine-1-carboxylic acid

반응식

[Cl:1]C1C2C(=CC=C(C=O)C=2)NC=1.C([O:17][C:18]([N:20]1[CH2:25][CH2:24][CH:23]([CH2:26][CH2:27][CH2:28][CH2:29][N:30]2[C:38]3[C:33](=[C:34]([CH:39]=[O:40])[CH:35]=[CH:36][CH:37]=3)[CH:32]=[CH:31]2)[CH2:22][CH2:21]1)=[O:19])(C)(C)C>>[Cl:1][C:32]1[C:33]2[C:38](=[CH:37][CH:36]=[CH:35][C:34]=2[CH:39]=[O:40])[N:30]([CH2:29][CH2:28][CH2:27][CH2:26][CH:23]2[CH2:24][CH2:25][N:20]([C:18]([OH:17])=[O:19])[CH2:21][CH2:22]2)[CH:31]=1

참가 물질

반응물 2

HCID 824092763-chloro-1H-indole-5-carbaldehyde

HCID 86631460HCID 86631460, 화합물

생성물 1

HCID 867614784-[4-(3-Chloro-4-formyl-indol-1-yl)-butyl]-piperidine-1-carboxylic acid

실험 절차

The title compound was prepared using methods analogous to those described for Intermediate 1 from 4-[4-(4-formyl-indol-1-yl)-butyl]-piperidine-1-carboxylic acid tert-butyl ester. MS: mass calcd. for C23H31ClN2O3, 418.20; m/z found, 441.3 [M+Na]+.

출처 및 근거

ORD 기록: ord-5f3712e5831545109a39077d9c31df95
출처 데이터셋: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08084466B2

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