2-Bromo-N-pyrimidin-4-yl-acetamide → (R)-3-Hydroxy-1-(pyrimidin-4-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide

반응식

[Br-].[OH:2][C@@H:3]1[CH:8]2[CH2:9][CH2:10][N+:5]([CH2:11][C:12](=[O:19])[NH:13][C:14]3[CH:18]=[CH:17]O[N:15]=3)([CH2:6][CH2:7]2)[CH2:4]1.[Br:20]C[C:22]([NH:24]C1C=CN=CN=1)=O>>[Br-:20].[OH:2][C@@H:3]1[CH:8]2[CH2:9][CH2:10][N+:5]([CH2:11][C:12](=[O:19])[NH:13][C:14]3[CH:18]=[CH:17][N:24]=[CH:22][N:15]=3)([CH2:6][CH2:7]2)[CH2:4]1

참가 물질

반응물 2

HCID 445419272-Bromo-N-pyrimidin-4-yl-acetamide

HCID 86627857(R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide2회

생성물 1

HCID 86627870(R)-3-Hydroxy-1-(pyrimidin-4-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide

실험 절차

This compound was prepared by an analogous method to (R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide (Intermediate A) by replacing 2-bromo-N-isoxazol-3-yl-acetamide (Ai) with 2-bromo-N-pyrimidin-4-yl-acetamide (Qi).

출처 및 근거

ORD 기록: ord-6e6062a380bf42548272c4cd8307ed13
출처 데이터셋: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08084463B2

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