2-bromo-N-(isoxazol-3-yl)acetamide → 3-[2-Hydroxy-2,2-bis-(3-methoxy-phenyl)-acetoxy]-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide
반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([O:9][C:10](=[O:29])[C:11]([OH:28])([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1)[CH2:2]2.[Br:30][CH2:31][C:32]([NH:34][C:35]1[CH:39]=[CH:38][O:37][N:36]=1)=[O:33]>C(#N)C>[Br-:30].[OH:28][C:11]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[CH:21]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=1)[C:10]([O:9][CH:3]1[CH:4]2[CH2:7][CH2:8][N+:1]([CH2:31][C:32](=[O:33])[NH:34][C:35]3[CH:39]=[CH:38][O:37][N:36]=3)([CH2:6][CH2:5]2)[CH2:2]1)=[O:29]참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
To a stirred solution of hydroxy-bis-(3-methoxy-phenyl)-acetic acid (R)-(1-aza-bicyclo[2.2.2]-oct-3-yl)ester (Intermediate K) (0.25 g, 0.63 mmol) in acetonitrile (10 ml) is added 2-bromo-N-isoxazol-3-yl-acetamide (0.15 g, 0.73 mmol) and the reaction mixture stirred at room temperature for 3 hours. The resulting precipitate is removed by filtration and the mother liquor is left at room temperature for 72 hours to crystallise. The crystals are filtered and dried in vacuo to yield the titled compound as a solid.