Acetonitrile → 1-Benzyl-6-chloroimidazo[1,2-a]pyridinium bromide

HRID 66014노트

반응식

HRID 66014 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[Br:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(#N)C>C(OCC)C>[Br-:11].[CH2:12]([N+:10]1[CH:9]=[CH:8][N:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=12)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 6342AcetonitrileHCID 7498Benzyl BromideHCID 27643286-Chloroimidazo(1,2-a)pyridine

생성물 1

HCID 203955731-Benzyl-6-chloroimidazo[1,2-a]pyridinium bromide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 2.3 g. of 6-chloroimidazo[1,2-a]pyridine and 3.42 g. of α-bromotoluene in 40 ml. of dry acetonitrile is heated at reflux temperatures overnight. The solution is cooled and 35 ml. of diethyl ether added. The precipitated solids are collected and twice recrystallized from isopropanoldiethyl ether, 3.8 g., m.p. 193°-195° C.

후처리

  1. temperatureat reflux temperatures overnight
  2. temperatureThe solution is cooled
  3. customThe precipitated solids are collected
  4. customtwice recrystallized from isopropanoldiethyl ether, 3.8 g

출처 및 근거

ORD 기록
ord-0faca37a6e124296a96b2b3064178b99
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129567

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