HCID 57742139, 화합물 → HCID 12370790, 화합물

HRID 660285노트

반응식

HRID 660285 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>[C].[Pd].C1COCC1.CCO>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:3][C:2]=1[OH:1]

참가 물질

4

반응물 1

HCID 57742139HCID 57742139, 화합물

생성물 1

HCID 12370790HCID 12370790, 화합물

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 21873804Tetrahydrofuran ethanol용매

실험 절차

To the flask was added THF/EtOH (1:1, 30 mL) followed by Ethyl 2-(3-hydroxy-4-nitrophenyl)propanoate (900 mg, 3.76 mmol) and 10% palladium carbon (93 mg) at room temperature. The reaction mixture was hydrogenated and stirred for 1 hrs at 46 psi then filtered through celite bed, and washed with EtOAc. The filtrate was concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using EtOAc:hexanes (1:2) as eluant.

후처리

  1. filtrationthen filtered through celite bed
  2. washwashed with EtOAc
  3. concentrationThe filtrate was concentrated in vacuo
  4. customThe residue was purified by flash column chromatography on silica gel

출처 및 근거

ORD 기록
ord-32cc5fc129034436b707186d0896cd03
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084484B2

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