Potassium Carbonate → HCID 57742155, 화합물

HRID 660287노트

반응식

HRID 660287 반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([CH3:18])[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:8][C:7]=1[OH:19])=[O:4].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.O>[O:4]=[C:3]1[CH2:2][O:19][C:7]2[CH:8]=[C:9]([CH:12]([CH3:18])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:10]=[CH:11][C:6]=2[NH:5]1

참가 물질

5

반응물 2

HCID 11430Potassium CarbonateHCID 57742180HCID 57742180, 화합물

생성물 1

HCID 57742155HCID 57742155, 화합물

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매

실험 절차

A solution of ethyl 2-(4-(2-chloroacetamido)-3-hydroxyphenyl)propanoate (110 mg, 0.385 mmol) in acetone (10 mL) was added potassium carbonate (61 mg). the reaction mixture was refluxed for 3 hrs then cooled to room temperature. The mixture was diluted with H2O and extracted with EtOAc. The organic layer was dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using EtOAc:hexanes (1:2) as eluent.

후처리

  1. temperaturethe reaction mixture was refluxed for 3 hrs
  2. extractionextracted with EtOAc
  3. dry with materialThe organic layer was dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified by flash column chromatography on silica gel

출처 및 근거

ORD 기록
ord-f9b4c14b10954a1d9b818652dd0eacec
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084484B2

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