Ethyl 2-(4-hydroxy-3-nitrophenyl)propanoate → Ethyl 3-amino-4-hydroxy-phenyl-propionate

HRID 660292노트

반응식

HRID 660292 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][C:3]=1[N+:15]([O-])=O>C1COCC1.C(O)C.[Pd]>[NH2:15][C:3]1[CH:4]=[C:5]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:7][C:2]=1[OH:1]

참가 물질

5

반응물 1

HCID 21444155Ethyl 2-(4-hydroxy-3-nitrophenyl)propanoate

생성물 1

HCID 12202638Ethyl 3-amino-4-hydroxy-phenyl-propionate

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl 2-(4-hydroxy-3-nitrophenyl)propanoate (260 mg, 1.09 mmol) in THF (6 mL) and ethanol (6 mL) was slowly added 10% Pd/C (29 mg) at room temperature. The mixture was hydrogenated for 2 hours at 43 psi and then filtered with celite pad and washed with EtOAc. The filtrate was concentrated in vacuo. The residue was purified by column chromatography eluting with n-Hexane/EtOAc=1/1.

후처리

  1. customat room temperature
  2. filtrationfiltered with celite pad
  3. washwashed with EtOAc
  4. concentrationThe filtrate was concentrated in vacuo
  5. customThe residue was purified by column chromatography
  6. washeluting with n-Hexane/EtOAc=1/1

출처 및 근거

ORD 기록
ord-d260cc7546d1492e9c9807a0e78c78e1
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084484B2

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