Ethyl 2-(4-amino-3-nitrophenyl)propanoate → Ethyl 2-(3,4-diaminophenyl)propanoate

HRID 660301노트

반응식

HRID 660301 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][C:3]=1[N+:15]([O-])=O>[C].[Pd].C1COCC1.CCO>[NH2:15][C:3]1[CH:4]=[C:5]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:7][C:2]=1[NH2:1]

참가 물질

4

반응물 1

HCID 15558027Ethyl 2-(4-amino-3-nitrophenyl)propanoate

생성물 1

HCID 12226827Ethyl 2-(3,4-diaminophenyl)propanoate

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 21873804Tetrahydrofuran ethanol용매

실험 절차

To the flask was added THF/EtOH (1:1, 50 mL) followed by Ethyl 2-(4-amino-3-nitrophenyl)propanoate (2.12 g, 8.90 mmol) and 10% palladium carbon (220 mg) at room temperature. The reaction mixture was hydrogenated and stirred for 3 hrs at 45 psi then filtered through celite bed, and washed with EtOH. The filtrate was concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using EtOAc:hexanes (1:4-1:2) as eluant.

후처리

  1. filtrationthen filtered through celite bed
  2. washwashed with EtOH
  3. concentrationThe filtrate was concentrated in vacuo
  4. customThe residue was purified by flash column chromatography on silica gel

출처 및 근거

ORD 기록
ord-685bce2855ad48f2825085c436acc721
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084484B2

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