Nitric Acid → HCID 57742139, 화합물

HRID 660311노트

반응식

HRID 660311 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[CH:6][CH:7]=1.[N+:15]([O-])([OH:17])=[O:16]>C(O)(=O)C>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[CH:6][C:7]=1[N+:15]([O-:17])=[O:16]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 13356241HCID 13356241, 화합물

생성물 1

HCID 57742139HCID 57742139, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Ethyl 2-(3-hydroxyphenyl)propanoate (2.51 g, 12.9 mmol) in acetic acid (20 mL) was added nitric acid (60-62%, 1.45 g, 13.8 mmol) at room temperature. The mixture was stirred for 15 minutes at room temperature. The reaction mixture was poured into ice water (100 mL) and extracted with EtOAc. The organic layer was dried with MgSO4 and filtered. EtOAc was removed by evaporation. The residue was purified by column chromatography eluting with n-Hexane/EtOAc=6/1.

후처리

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layer was dried with MgSO4
  3. filtrationfiltered
  4. customEtOAc was removed by evaporation
  5. customThe residue was purified by column chromatography
  6. washeluting with n-Hexane/EtOAc=6/1

출처 및 근거

ORD 기록
ord-9c4ab8006cd3451dafe562dfd24a62fe
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084484B2

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