Nitric Acid → HCID 57742139, 화합물

HRID 660323노트

반응식

HRID 660323 반응식
[CH2:1]([O:3][C:4](=[O:14])[CH:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([OH:13])[CH:8]=1)[CH3:6])[CH3:2].[N+:15]([O-])([OH:17])=[O:16].O>C(O)(=O)C>[CH2:1]([O:3][C:4](=[O:14])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([N+:15]([O-:17])=[O:16])=[C:9]([OH:13])[CH:8]=1)[CH3:6])[CH3:2]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 962WaterHCID 13356241HCID 13356241, 화합물

생성물 1

HCID 57742139HCID 57742139, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 2-(3-Hydroxy-phenyl)-propionic acid ethyl ester (19.0 g) in acetic acid (150 mL) was added nitric acid (11.3 g) at room temperature. The reaction mixture was stirred for 1 h at room temperature and added water. The mixture was extracted with EtOAc and the organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo. The resulting residue was chromatographed on silica gel (n-Hex:EtOAc=10:1) to afford the product as yellow solid. (6.08 g, 26.0%)

후처리

  1. extractionThe mixture was extracted with EtOAc
  2. dry with materialthe organic layer was dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customThe resulting residue was chromatographed on silica gel (n-Hex:EtOAc=10:1)

출처 및 근거

ORD 기록
ord-006af1c787c4479ea159671ebdf48058
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084484B2

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