Ethyl 2-(4-nitrophenyl)propionate → Ethyl 2-(4-aminophenyl)propanoate

HRID 660333노트

반응식

HRID 660333 반응식
[CH2:1]([O:3][C:4](=[O:16])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=1)[CH3:6])[CH3:2]>C1COCC1.CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:16])[CH:5]([C:7]1[CH:8]=[CH:9][C:10]([NH2:13])=[CH:11][CH:12]=1)[CH3:6])[CH3:2]

참가 물질

5

반응물 1

HCID 3016550Ethyl 2-(4-nitrophenyl)propionate

생성물 1

HCID 118009Ethyl 2-(4-aminophenyl)propanoate

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 2-(4-Nitro-phenyl)-propionic acid ethyl ester (3.67 g) in THF (40 mL) and EtOH (40 mL) was slowly added 10% Pd/C (405 mg) at room temperature. After hydrogenated for 20 h with H2 balloon, the reaction mixture was filtered through celite pad and washed with EtOAc. The organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo. The resulting residue was chromatographed on silica gel (n-Hex:EtOAc=4:1) to afford the product as pale yellow oil. (99.7%)

후처리

  1. customat room temperature
  2. filtrationthe reaction mixture was filtered through celite pad
  3. washwashed with EtOAc
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe resulting residue was chromatographed on silica gel (n-Hex:EtOAc=4:1)

출처 및 근거

ORD 기록
ord-44bafbe5e0f84d9c9564330cb98c8fdc
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084484B2

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