2-(4-Nitrophenyl)propiononitrile → 2-(4-Aminophenyl)propiononitrile
반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:13])[C:11]#[N:12])=[CH:6][CH:5]=1)([O-])=O>[C].[Pd].C1COCC1.CCO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:13])[C:11]#[N:12])=[CH:8][CH:9]=1참가 물질
4
실험 절차
To the flask was added THF/EtOH (1:1, 70 mL) followed by 2-(4-nitrophenyl)-propionitrile (13.2 g, 74.9 mmol) and 10% palladium carbon (1.07 g) at room temperature. The reaction mixture was hydrogenated and stirred for 30 minutes at 47 psi to 28 psi then filtered through celite bed, and washed with EtOAc. The filtrate was concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using EtOAc:hexanes (1:3) as eluant.
후처리
- filtrationthen filtered through celite bed
- washwashed with EtOAc
- concentrationThe filtrate was concentrated in vacuo
- customThe residue was purified by flash column chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-22174395b9b44522b5d27eb1656ec346
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08084484B2
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