Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 660545생성일: 2026년 10월 26일
Cesium fluoride → 5-[2-Benzyloxy-4-(6-benzyloxypyridin-2-ylmethyl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one
https://huagongshe.com/reaction/660545
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium fluoride | HCID 25953 | — |
| 반응물 | 5-[2-Benzyloxy-4-(6-benzyloxypyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one | HCID 68838834 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-[2-Benzyloxy-4-(6-benzyloxypyridin-2-ylmethyl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one | HCID 66757119 | — |
반응 단계
To a solution of 5-[2-benzyloxy-4-(6-benzyloxypyridin-2-ylmethyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one (213 mg, 0.35 mmol) in DMF (3 mL) is added CsF (265 mg, 1.75 mmol). The reaction is stirred at 60° C. for 2 h. The reaction is allowed to cool to RT and the solvent is removed under reduced pressure. The crude cesium salt of the title compound is used in the next step without further purification: (M+H)+=516.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08084448B2 |
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| 출처 데이터셋 | uspto-grants-2011_12 |
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| ORD ID | ord-df3f2f0f04754981acdef5cf890756c8 |
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| 출처 메모 | uspto-grants-2011_12 |
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