Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 660572생성일: 2026년 10월 26일
Potassium Acetate → 7-Oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxylic Acid Methyl Ester
https://huagongshe.com/reaction/660572
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Acetate | HCID 517044 | — |
| 반응물 | (2-Iodobenzoylamino)-(2-iodophenyl)-acetic Acid Methyl Ester | HCID 68839341 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-Oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxylic Acid Methyl Ester | HCID 68838469 | — |
반응 단계
To a solution of (2-iodobenzoylamino)-(2-iodophenyl)-acetic acid methyl ester (3.4 g, 6.53 mmol) in DMF (300 mL) under argon is added PdCl2(dppf) (269 mg, 0.33 mmol) and KOAc (1.28 g, 13.06 mmol) and the mixture is heated at 110° C. for 18 h. Additional PdCl2(dppf) is added and heating is continued until all starting material is consumed. The solvent is removed under reduced pressure and the residue purified by flash chromatography using a gradient of 0-50% MeOH/methylene chloride as eluent to give the title compound as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08084448B2 |
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| 출처 데이터셋 | uspto-grants-2011_12 |
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| ORD ID | ord-f5e80b2965294fee9b2c92aaa0c2d7ed |
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| 출처 메모 | uspto-grants-2011_12 |
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