Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 660589생성일: 2026년 10월 24일
Triethylamine → 2-((E)-4-{3-Benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-phenyl}-but-3-enyl)-isoindole-1,3-dione
https://huagongshe.com/ko/reaction/660589
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | N-(3-Buten-1-yl)phthalimide | HCID 339432 | — |
| 반응물 | 5-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one | HCID 66756937 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-((E)-4-{3-Benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-phenyl}-but-3-enyl)-isoindole-1,3-dione | HCID 68838751 | — |
반응 단계
To a solution of 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one (100 mg, 0.184 mmol) in MeCN (5 mL) in a pressure tube is added 2-but-3-enylisoindole-1,3-dione (41 mg, 0.202 mmol), Pd(OAc)2 (3 mg) and triethylamine (186 mg, 1.84 mmol) then the mixture is heated at 100° C. for 10 h. The solvent is removed under reduced pressure and the residue is purified by flash chromatography using a gradient of 20-40% EtOAc/hexane as eluent to give the title compound: (M+NH4)+=635.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08084448B2 |
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| 출처 데이터셋 | uspto-grants-2011_12 |
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| ORD ID | ord-2ff1d6f34c3642f49b908cdc4db0f860 |
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| 출처 메모 | uspto-grants-2011_12 |
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