Water → 2,6-Bis-benzyloxybenzoic Acid Benzyl Ester

HRID 660617

반응식

HRID 660617 반응식
O[C:2]1[CH:10]=[CH:9][CH:8]=[C:7](O)[C:3]=1[C:4](O)=[O:5].[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[C:20]([O-:23])([O-])=[O:21].[K+].[K+].[OH2:26]>CN(C=O)C>[CH2:12]([O:23][C:20](=[O:21])[C:2]1[C:10]([O:26][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:9][CH:8]=[CH:7][C:3]=1[O:5][CH2:4][C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:2]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 93382,6-Dihydroxybenzoic AcidHCID 11430Potassium Carbonate

생성물 1

HCID 145620262,6-Bis-benzyloxybenzoic Acid Benzyl Ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 2,6-dihydroxybenzoic acid (1.54 g, 10 mmol) and benzyl bromide (3.63 mL, 30.5 mmol) in DMF (20 mL) is added K2CO3 (4.83 g, 30.5 mmol) and the mixture is stirred at RT for 48 h. Water is added and the mixture is extracted with EtOAc. The organic phase is washed with water and brine then is dried over sodium sulfate. The solvent is removed under reduced pressure and the residue is purified by flash chromatography using hexane/EtOAc (8:1) as eluent to give the title compound.

후처리

  1. extractionthe mixture is extracted with EtOAc
  2. washThe organic phase is washed with water and brine
  3. dry with materialthen is dried over sodium sulfate
  4. customThe solvent is removed under reduced pressure
  5. customthe residue is purified by flash chromatography

출처 및 근거

ORD 기록
ord-a81e8126fd804bb4b76982e317e953de
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084448B2

연결된 노트

불러오는 중…