Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 2,6-Dihydroxybenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Hydroxylamine, sulfate (1:1) | HCID 159255 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 2,6-Dihydroxybenzaldehyde | HCID 10285801 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2,6-Dihydroxybenzonitrile | HCID 93791 | — |
반응 단계
A mixture of 2,6-dihydroxybenzaldehyde (300 mg, 2.17 mmol) and hydroxylamine sulfate (758 mg, 6.51 mmol) in water (30 mL) is stirred at RT for 45 min. Methylene chloride (60 mL) is added followed by NaHCO3 (911 mg, 10.85 mmol) and the mixture is stirred at RT for 30 min. The organic phase is separated and dried over sodium sulfate and the solvent removed under reduced pressure to give the title compound as a pale yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08084448B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-debdfd5d2d5f45438a483499e7fa3ccd |
| 출처 메모 | uspto-grants-2011_12 |