Dichloromethane → 2,6-Dihydroxybenzonitrile

HRID 660621

반응식

HRID 660621 반응식
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:3]=1[CH:4]=O.S(O)(O)(=O)=O.[NH2:16]O.C(Cl)Cl.C([O-])(O)=O.[Na+]>O>[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:3]=1[C:4]#[N:16]

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 159255Hydroxylamine, sulfate (1:1)HCID 516892Sodium BicarbonateHCID 102858012,6-Dihydroxybenzaldehyde

생성물 1

HCID 937912,6-Dihydroxybenzonitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 2,6-dihydroxybenzaldehyde (300 mg, 2.17 mmol) and hydroxylamine sulfate (758 mg, 6.51 mmol) in water (30 mL) is stirred at RT for 45 min. Methylene chloride (60 mL) is added followed by NaHCO3 (911 mg, 10.85 mmol) and the mixture is stirred at RT for 30 min. The organic phase is separated and dried over sodium sulfate and the solvent removed under reduced pressure to give the title compound as a pale yellow solid.

후처리

  1. stirringthe mixture is stirred at RT for 30 min
  2. customThe organic phase is separated
  3. dry with materialdried over sodium sulfate
  4. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-debdfd5d2d5f45438a483499e7fa3ccd
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084448B2

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