HCID 68842200, 화합물 → HCID 57777470, 화합물

HRID 660794노트

반응식

HRID 660794 반응식
C([O:8][C:9]1[CH:10]=[C:11]([CH:21]=[CH:22][C:23]=1[N:24]1[CH2:28][C:27](=[O:29])[NH:26][S:25]1(=[O:31])=[O:30])[CH2:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[C:15]#[N:16])C1C=CC=CC=1>CCO.O.[Pd]>[NH2:16][CH2:15][C:14]1[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=1[CH2:12][C:11]1[CH:21]=[CH:22][C:23]([N:24]2[S:25](=[O:31])(=[O:30])[NH:26][C:27](=[O:29])[CH2:28]2)=[C:9]([OH:8])[CH:10]=1

참가 물질

4

반응물 1

HCID 68842200HCID 68842200, 화합물

생성물 1

HCID 57777470HCID 57777470, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 19096565Water ethanol용매

실험 절차

A solution of 2-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-benzonitrile in EtOH/water (1:1) is hydrogenated at 1 atm over 10% Pd/C for 40 min. The catalyst is filtered, the solvent evaporated and the residue purified by preparative HPLC to give the title compound.

후처리

  1. filtrationThe catalyst is filtered
  2. customthe solvent evaporated
  3. customthe residue purified by preparative HPLC

출처 및 근거

ORD 기록
ord-db52030bf3ee440296d30a80d4a44909
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084448B2

반응 노트

불러오는 중…