4-Chlorobenzohydrazide → HCID 47133870, 화합물

HRID 660838

반응식

HRID 660838 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][CH:3]=1.[CH:12]1([N:15]=[C:16]=[O:17])[CH2:14][CH2:13]1>O1CCCC1>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH:9][C:16]([NH:15][CH:12]2[CH2:14][CH2:13]2)=[O:17])=[O:7])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 108164-ChlorobenzohydrazideHCID 637659Isocyanatocyclopropane

생성물 1

HCID 47133870HCID 47133870, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
50 °C

실험 절차

Under an argon atmosphere, 4.00 g (23.4 mmol) of 4-chlorobenzoic acid hydrazide are placed in 50 ml tetrahydrofuran. 1.95 g (23.4 mmol) of cyclopropyl isocyanate, dissolved in 50 ml tetrahydrofuran, are added dropwise at 50° C., and the mixture further stirred overnight at 50° C. The solvent is evaporated in vacuo, diethyl ether is added to the residue and the solid formed is isolated and purified by filtration and further washing with diethyl ether. 5.92 g (ca. 100% of theory) of the target compound are thus obtained.

후처리

  1. additionare added dropwise at 50° C.
  2. customThe solvent is evaporated in vacuo, diethyl ether
  3. additionis added to the residue
  4. customthe solid formed
  5. customis isolated
  6. filtrationpurified by filtration
  7. washfurther washing with diethyl ether
  8. custom5.92 g (ca. 100% of theory) of the target compound are thus obtained

출처 및 근거

ORD 기록
ord-814020fe38114f1f9d9dedf11305c678
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084481B2

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