3-Chlorobenzohydrazide → HCID 47131865, 화합물

HRID 660839

반응식

HRID 660839 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH2:8])=[O:6].[CH:12]1([N:15]=[C:16]=[O:17])[CH2:14][CH2:13]1>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH:8][C:16]([NH:15][CH:12]1[CH2:14][CH2:13]1)=[O:17])=[O:6]

참가 물질

4

반응물 2

HCID 742893-ChlorobenzohydrazideHCID 637659Isocyanatocyclopropane

생성물 1

HCID 47131865HCID 47131865, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Under an argon atmosphere, 430 mg (2.52 mmol) of 3-chlorobenzoic acid hydrazide are placed in 6 ml tetrahydrofuran. 209 mg (2.52 mmol) of cyclopropyl isocyanate, dissolved in 2 ml tetrahydrofuran is added dropwise and further stirred overnight at room temperature. It is concentrated and purified by stirring the residue with diethyl ether, filtration, further washing with diethyl ether and drying in vacuo. 514 mg (80% of theory) of the target compound are thus obtained.

후처리

  1. additionis added dropwise and further stirred overnight at room temperature
  2. concentrationIt is concentrated
  3. custompurified
  4. filtrationwith diethyl ether, filtration
  5. washfurther washing with diethyl ether
  6. customdrying in vacuo
  7. custom514 mg (80% of theory) of the target compound are thus obtained

출처 및 근거

ORD 기록
ord-c617a670b8b54eb2adcb26308e061f78
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084481B2

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