Diethyl Ether → 2-(2-phenylbenzoyl)-N-isobutylhydrazinecarboxamide

HRID 660844

반응식

HRID 660844 반응식
[C:1]1([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([NH:11][NH2:12])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:17]([N:21]=[C:22]=[O:23])[CH:18]([CH3:20])[CH3:19].C(OCC)C.C1CCCCC1>O1CCCC1>[C:1]1([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([NH:11][NH:12][C:22]([NH:21][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:23])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 8078CyclohexaneHCID 612812-Methylpropyl isocyanateHCID 27603652-Phenylbenzhydrazide

생성물 1

HCID 486138272-(2-phenylbenzoyl)-N-isobutylhydrazinecarboxamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

1.00 g (4.71 mmol) of 2-phenylbenzoic acid hydrazide are placed in 10 ml tetrahydrofuran at room temperature. 0.51 g (5.15 mmol) of isobutyl isocyanate, dissolved in 2 ml tetrahydrofuran, are rapidly added dropwise with stirring. The mixture is firstly stirred further at room temperature and then allowed to stand overnight. Addition of an equal volume of diethyl ether and 10 ml of cyclohexane results in separation of a small quantity of a solid, which is filtered off and discarded. Concentration of the filtrate yields 1.53 g (ca. 100% of theory) of a slightly THF-moist product, which is used further as such.

후처리

  1. additionare rapidly added dropwise
  2. stirringThe mixture is firstly stirred further at room temperature
  3. customresults in separation of a small quantity of a solid, which
  4. filtrationis filtered off
  5. customConcentration of the filtrate yields 1.53 g (ca. 100% of theory) of a slightly THF-moist product, which

출처 및 근거

ORD 기록
ord-005a66039c134a6c96c57ede4e85a2c5
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084481B2

연결된 노트

불러오는 중…