Isocyanatocyclopropane → Ethyl [4-(4-chlorophenyl)-3-cyclopropyl-5-methyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate

HRID 660872노트

반응식

HRID 660872 반응식
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][NH:6][CH:7]([CH3:17])[C:8]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)=O)[CH3:2].[CH:19]1([N:22]=[C:23]=[O:24])[CH2:21][CH2:20]1>O1CCCC1>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][N:6]1[C:7]([CH3:17])=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[N:22]([CH:19]2[CH2:21][CH2:20]2)[C:23]1=[O:24])[CH3:2]

참가 물질

4

반응물 2

HCID 637659IsocyanatocyclopropaneHCID 57455730N-[2-(4-chlorophenyl)-1-methyl-2-oxoethyl]-glycine ethyl ester

생성물 1

HCID 58012249Ethyl [4-(4-chlorophenyl)-3-cyclopropyl-5-methyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

355 mg (1.32 mmol) of N-[2-(4-chlorophenyl)-1-methyl-2-oxoethyl]-glycine ethyl ester from Example 117A are placed in 5 ml tetrahydrofuran, treated with 109 mg (1.32 mmol) of cyclopropyl isocyanate and stirred overnight at room temperature. The reaction mixture is evaporated and the residue purified by flash chromatography on silica gel (eluent: first dichloromethane, then dichloromethane/methanol 200:1→100:1). 425 mg (91% of theory) of the target compound are thus obtained.

후처리

  1. customThe reaction mixture is evaporated
  2. customthe residue purified by flash chromatography on silica gel (eluent
  3. custom425 mg (91% of theory) of the target compound are thus obtained

출처 및 근거

ORD 기록
ord-11ca6f622d1c4fcfa245cc9680d0d1a1
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084481B2

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