Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Amantadine → N-(4-nitrophenyl)adamantan-1-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Amantadine | HCID 2130 | — |
| 반응물 | p-Fluoronitrobenzene | HCID 9590 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Hexamethylphosphoramide | HCID 12679 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-(4-nitrophenyl)adamantan-1-amine | HCID 12510269 | — |
반응 단계
A mixture of 1.51 g. (0.01 mole) of 1-adamantamine, 1.41 g. p-fluoronitrobenzene and 1.38 g. K2CO3 in 10 ml. HMPA was stirred overnight in an oil bath at 135°. The mixture was allowed to cool, diluted with H2O and extracted thoroughly with C6H6. The organic layer was washed in turn with H2O and brine and taken to dryness. The waxy residue was recrystallized twice from Me2CO:cyclohexane to give 1.82 g. (67%) of N,1-adamantyl-p-nitroaniline, m.p. 188°-189°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04130561 |
| 출처 데이터셋 | uspto-grants-1978_12 |
| ORD ID | ord-17014710960f4dae85ffe803714eb7bb |
| 출처 메모 | uspto-grants-1978_12 |