Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → p-[(2-Methyl-2-norbornyl]oxy)nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | p-Fluoronitrobenzene | HCID 9590 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Norbornanol | HCID 79028 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | p-[(2-Methyl-2-norbornyl]oxy)nitrobenzene | HCID 70588011 | — |
반응 단계
To a solution of 15.6 g. (0.10 mole) of the crude norborneol in 80 ml. DMF and 160 ml. C6H6 there was added 4.21 g. of 56% NaH dispersion. Following 30 minutes heating at reflux, there was added 14.1 g. of p-fluoronitrobenzene. The mixture was then heated for an additional 6 hours, cooled and washed thoroughly with H2O and brine. The residue was chromatographed on 2 L silica gel (elution with 1:1 SSB:C6H6). Those fractions which showed a single spot on tlc were combined to afford 13.5 g. of product as a yellow oil; the NMR is in agreement with the structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04130561 |
| 출처 데이터셋 | uspto-grants-1978_12 |
| ORD ID | ord-3356b2cd294448be9c04bd9d6f95154f |
| 출처 메모 | uspto-grants-1978_12 |