반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:16]([CH3:17])=[CH:15][C:14]([OH:18])=[CH:13][C:12]=2[CH3:19])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].CO[C:22]([C:24]1[S:25][C:26]([CH:29]([CH2:32]O)[CH2:30][CH3:31])=[CH:27][CH:28]=1)=[O:23].Cl.[CH3:35][O:36][C:37](=[O:41])[CH2:38][CH2:39][NH2:40]>>[CH3:35][O:36][C:37](=[O:41])[CH2:38][CH2:39][NH:40][C:22]([C:24]1[S:25][C:26]([CH:29]([CH2:32][O:18][C:14]2[CH:13]=[C:12]([CH3:19])[C:11]([C:8]3[CH:7]=[CH:6][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:10][CH:9]=3)=[C:16]([CH3:17])[CH:15]=2)[CH2:30][CH3:31])=[CH:27][CH:28]=1)=[O:23]참가 물질
4
반응물 3
생성물 1
실험 절차
This compound is made by the general method as exemplified in Preparation 94 using 4′-tert-butyl-2,6-dimethyl-biphenyl-4-ol and 5-(1-hydroxymethyl-propyl)-thiophene-2-carboxylic acid methyl ester in Step A and 3-amino-propionic acid methyl ester hydrochloride salt in Step C as the starting materials to provide (±)-3-({5-[1-(4′-tert-butyl-2,6-dimethyl-biphenyl-4-yloxymethyl)-propyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (0.213 g) as a white solid. MS (ES): 520.3 [M−H]−. The racemic material is separated by chiral HPLC (column: Chiralpak AD-H 4.6×150 mm; eluent: 20:80 IPA/supercritical CO2; flow rate: 5 mL/min; UV absorbance wavelength: 270 nm) to provide Isomer 1 (0.074 g, >99% ee) and Isomer 2 (0.078 g, >99% ee).
출처 및 근거
- ORD 기록
- ord-cd9b7e1f985e403c97904a56b4f4deea
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08084489B2
연결된 노트
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