Ammonium Chloride → 1,2,3,4-Tetrahydro-6-hydroxy-2-[(4-phenyl-1-piperazinyl)methyl]-1-naphthalenol

HRID 66115노트

반응식

HRID 66115 반응식
C([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]([OH:15])[CH:10]([CH2:16][N:17]1[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:19][CH2:18]1)[CH2:9][CH2:8]2)(=O)C.[Cl-].[NH4+]>[OH-].[K+].O>[OH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]([OH:15])[CH:10]([CH2:16][N:17]1[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:19][CH2:18]1)[CH2:9][CH2:8]2

참가 물질

5

반응물 2

HCID 25517Ammonium ChlorideHCID 227555641,2,3,4-Tetrahydro-6-acetoxy-2-[(4-phenyl-1-piperazinyl)methyl]-1-naphthalenol

생성물 1

HCID 227555881,2,3,4-Tetrahydro-6-hydroxy-2-[(4-phenyl-1-piperazinyl)methyl]-1-naphthalenol

시약·촉매·용매 2

HCID 962Water용매HCID 14797Potassium Hydroxide용매

실험 절차

1,2,3,4-Tetrahydro-6-acetoxy-2-[(4-phenyl-1-piperazinyl)methyl]-1-naphthalenol (3.96 g) in 32 ml of 8% methanolic potassium hydroxide is refluxed for 3 minutes under argon, cooled to room temperature and diluted with sufficient water to effect solution. Excess aqueous ammonium chloride solution is added dropwise, with stirring, and the reaction mixture is extracted several times with methylene chloride. The organic extracts are dried, filtered and evaporated to give the title A compound.

후처리

  1. extractionthe reaction mixture is extracted several times with methylene chloride
  2. customThe organic extracts are dried
  3. filtrationfiltered
  4. customevaporated
  5. customto give the title A compound

출처 및 근거

ORD 기록
ord-80e8e50a194049f2ae57718d42a636ea
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04130646

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