Potassium Carbonate → N-phenethyl-N-propyl-3-methoxyphenethylamine

HRID 66127

반응식

HRID 66127 반응식
[CH2:1](I)[CH2:2][CH3:3].C(=O)([O-])[O-].[K+].[K+].[CH2:11]([NH:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=1)[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CC(C)=O>[CH2:11]([N:19]([CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=1)[CH2:1][CH2:2][CH3:3])[CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 12477997N-phenethyl-3-methoxyphenethylamine

생성물 1

HCID 12478003N-phenethyl-N-propyl-3-methoxyphenethylamine

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

1.1 ml of propyl iodide and 1.1 g of potassium carbonate were added to a solution of 1.1 g of the product of Step A in 15 ml of acetone and the mixture was refluxed with stirring for 5 hours. The acetone was distilled under reduced pressure and 50 ml of water were added thereto. The mixture was extracted 3 times with 20 ml of methylene chloride and the combined organic phases were washed with 70 ml of aqueous sodium chloride solution. The organic phases were dried over magnesium sulfate, filtered and evaporated to dryness under reduced pressure to obtain 1.25 g of N-phenethyl-N-propyl-3-methoxyphenethylamine in the form of an orange oil.

후처리

  1. temperaturethe mixture was refluxed
  2. distillationThe acetone was distilled under reduced pressure and 50 ml of water
  3. additionwere added
  4. extractionThe mixture was extracted 3 times with 20 ml of methylene chloride
  5. washthe combined organic phases were washed with 70 ml of aqueous sodium chloride solution
  6. dry with materialThe organic phases were dried over magnesium sulfate
  7. filtrationfiltered
  8. customevaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-513f67831ac641ba96946d2e51567ccf
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04130658

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