Potassium Carbonate → 3-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-N-propyl-benzene-ethanamine

HRID 66128노트

반응식

HRID 66128 반응식
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=2)=O)[CH:7]=[CH:8][CH:9]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:30](I)[CH2:31][CH3:32]>CC(C)=O>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][N:13]([CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=2)[CH2:30][CH2:31][CH3:32])[CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 227557503-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-benzene-ethanamide hydrochloride

생성물 1

HCID 124780053-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-N-propyl-benzene-ethanamine수율 97.3%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A suspension of 8.75 g of the product of Step A, 17.5 g of calcined neutral potassium carbonate, 17.5 g of propyl iodide and 180 ml of acetone was refluxed for 61/2 hours under nitrogen and the mixture was then filtered. The filtrate was evaporated to dryness and the residue was taken up in ether. The ether solution was washed with water, dried and evaporated to dryness to obtain 8.3 g of 3-methoxy-N-[2-(3-methoxyphenyl)-ethyl]-N-propyl-benzene-ethanamine which was used as is for the next step.

후처리

  1. temperaturewas refluxed for 61/2 hours under nitrogen
  2. filtrationthe mixture was then filtered
  3. customThe filtrate was evaporated to dryness
  4. washThe ether solution was washed with water
  5. customdried
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-5ee94f4a4866432ba586e76f53bf5f20
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04130658

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