5-Amino-2-hydroxy-2,4,6-cycloheptatrien-1-one → 2-(4-Hydroxy-5-oxo-1,3,6-cycloheptatrien-1-ylamino)-2-butenedioic Acid Diethyl Ester

HRID 66132

반응식

HRID 66132 반응식
[C:1]([C:8]([O:10][CH2:11][CH3:12])=[O:9])#[C:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[NH2:13][C:14]1[CH:20]=[CH:19][C:18](=[O:21])[C:17]([OH:22])=[CH:16][CH:15]=1>C(O)C>[CH2:6]([O:5][C:3](=[O:4])[C:2]([NH:13][C:14]1[CH:20]=[CH:19][C:18](=[O:21])[C:17]([OH:22])=[CH:16][CH:15]=1)=[CH:1][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:7]

참가 물질

4

반응물 2

HCID 234505-Amino-2-hydroxy-2,4,6-cycloheptatrien-1-oneHCID 69803Diethyl acetylenedicarboxylate

생성물 1

HCID 867362102-(4-Hydroxy-5-oxo-1,3,6-cycloheptatrien-1-ylamino)-2-butenedioic Acid Diethyl Ester

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of diethyl acetylenedicarboxylate (183.5 g) and 5-amino-2-hydroxy-2,4,6-cycloheptatriene-1-one [147.5 g, described by T. Nozoe et al., Science Repts. Tokoku Univ., First ser., 35, 274(1952)] in ethanol (2,700 ml) is stirred at room temperature for 16 hours. The mixture is filtered and the precipitate is crystallized from ethanol to obtain crystals of the title compound, mp 108.5° C.

후처리

  1. filtrationThe mixture is filtered
  2. customthe precipitate is crystallized from ethanol

출처 및 근거

ORD 기록
ord-10aa283fe0b041468ebb0880110df018
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04130649

연결된 노트

불러오는 중…