1,2-Benzenedicarboxylic acid, 4-nitro- → 4-Aminophthalic acid

HRID 66257

반응식

HRID 66257 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[C:7](=[CH:11][CH:12]=1)[C:8]([OH:10])=[O:9])([O-])=O>O1CCOCC1>[NH2:1][C:4]1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[C:7](=[CH:11][CH:12]=1)[C:8]([OH:10])=[O:9]

참가 물질

3

반응물 1

HCID 691211,2-Benzenedicarboxylic acid, 4-nitro-

생성물 1

HCID 729124-Aminophthalic acid수율 50%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

124.9 g (0.69 mol) of 4-aminophthalic acid freshly obtained by reduction of 4-nitrophthalic acid in dioxane are reacted with 109.8 g (0.72 mol) of cis-1,2,3,6-tetrahydrophthalic anhydride in the manner described in Example 9, and the product is worked up as follows: after the batch has stood for 20 hours, the clear reaction solution is concentrated in vacuo to approx. 200 ml and heated with 200 ml of acetic anhydride and 170 ml of pyridine to 60° C. for 10 hours. The solvents are then stripped off in vacuo and the solid residue is recrystallised from benzene, whereupon the yellow-coloured phthalic anhydride derivative is obtained in a yield of about 50%, melting point = 188° C.

출처 및 근거

ORD 기록
ord-d1feb88fd9394d4dba8cee87a2fe7358
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04131613

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