Triethylamine → N-{1-[2-(1H-Indol-3-yl)ethyl]piperidin-4-yl}methanesulfonamide

HRID 66302

반응식

HRID 66302 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[NH:12][CH:11]=2)[CH2:4][CH2:3]1.C(N(CC)CC)C.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>ClCCl>[NH:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:10]([CH2:9][CH2:8][N:5]2[CH2:6][CH2:7][CH:2]([NH:1][S:27]([CH3:26])(=[O:29])=[O:28])[CH2:3][CH2:4]2)=[CH:11]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 2154154-Piperidinamine, 1-(2-(1H-indol-3-yl)ethyl)-, hydrate

생성물 1

HCID 22754838N-{1-[2-(1H-Indol-3-yl)ethyl]piperidin-4-yl}methanesulfonamide수율 105.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To 3-[2-(4-Amino-1-piperidyl)ethyl]indole (1.307 g.) suspended in a solution of triethylamine (2 mls.) in dichloromethane (10 mls.) at room temperature with stirring was added methane sulphonyl chloride (0.570 g.) in dichloromethane (5 mls.). After stirring for 18 hours the solution was washed with water and the organic phase separated, dried and evaporated to yield the title compound (1.690 g.) as an oil. This was recrystallized from ethanolic hydrogen chloride as the hydrochloride salt (0.560 g., m.p. 241°-242° C.).

후처리

  1. stirringAfter stirring for 18 hours the solution
  2. washwas washed with water
  3. customthe organic phase separated
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-945371300be648fc962154efaeb99079
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04131680

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