Selenium Dioxide → 2-Ethoxyphenylglyoxal

HRID 66324노트

반응식

HRID 66324 반응식
C([O:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6])C.[Se](=O)=O.[O:16]1CCO[CH2:18][CH2:17]1>O.C(OCC)(=O)C>[CH2:17]([O:16][C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:5]([CH:4]=[O:3])=[O:6])[CH3:18]

참가 물질

6

반응물 3

HCID 24007Selenium DioxideHCID 312751,4-DioxaneHCID 1398412-Ethoxy-1-phenylethan-1-one

생성물 1

HCID 227549162-Ethoxyphenylglyoxal

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

2 g of 2-ethoxyacetophenone are dissolved in 20 ml of dioxane, and a solution of 2 g of selenium dioxide in one ml of water is added thereto. The solution is refluxed for 10 hours. After the reaction, insoluble materials are removed by filtration, and the filtrate is concentrated. The residue thus obtained is dissolved in ethyl acetate. The ethyl acetate solution is washed with water and then with an aqueous sodium bicarbonate solution and water. Then, said solution is dried and evaporated to remove solvent. 2.1 g of 2-ethoxyphenylglyoxal are obtained as a crude oil.

후처리

  1. temperatureThe solution is refluxed for 10 hours
  2. customAfter the reaction, insoluble materials
  3. customare removed by filtration
  4. concentrationthe filtrate is concentrated
  5. customThe residue thus obtained
  6. washThe ethyl acetate solution is washed with water
  7. customis dried
  8. customevaporated
  9. customto remove solvent

출처 및 근거

ORD 기록
ord-74c949b65bbb45b78134c4849088b0f2
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04131686

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