Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 66333생성일: 2026년 10월 26일
Sec-Butylamine → 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one
https://huagongshe.com/reaction/66333
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sec-Butylamine | HCID 24874 | — |
| 반응물 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone | HCID 23343637 | — |
| 용매 | Diisopropyl Ether | HCID 7914 | — |
| 생성물 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one | HCID 22754738 | — |
반응 단계
A mixture of 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (8.6 g.) and sec-butylamine (40 cc.) is heated at 65° C. until dissolution. The reaction mixture is then diluted with diisopropyl ether (240 cc.). The precipitate formed is filtered off and recrystallised from acetonitrile (60 cc.). 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one (3 g.), melting at 220°-222° C., is thus obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04131674 |
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| 출처 데이터셋 | uspto-grants-1978_12 |
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| ORD ID | ord-023d2509928949a9bbadc17115bc650a |
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| 출처 메모 | uspto-grants-1978_12 |
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