Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 66334생성일: 2026년 10월 25일
Diisopropyl Ether → 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-cyclopropylaminocarbonyloxy-isoindolin-1-one
https://huagongshe.com/reaction/66334
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropyl Ether | HCID 7914 | — |
| 반응물 | Cyclopropylamine | HCID 69828 | — |
| 반응물 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone | HCID 23343637 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-cyclopropylaminocarbonyloxy-isoindolin-1-one | HCID 22754756 | 81.4% |
반응 단계
Cyclopropylamine (2.85 g.) is added to a suspension of 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (4.3 g.) in acetonitrile (43 cc.), and the suspension obtained is stirred for 20 hours at a temperature of about 20° C. Diisopropyl ether (85 cc.) is then added, after which the insoluble product is filtered off and washed with diisopropyl ether (2 × 10 cc.). Recrystallisation from acetonitrile (130 cc.) gives 2-(7-chloro-1,8-naphthyridin-2-yl)-3-cyclopropylaminocarbonyloxy-isoindolin-1-one (3.2 g.) melting at 220° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04131674 |
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| 출처 데이터셋 | uspto-grants-1978_12 |
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| ORD ID | ord-7bd64299fee340e4a2ee47755d6db096 |
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| 출처 메모 | uspto-grants-1978_12 |
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