Nitric Acid → 6-Methyl-2-nitropyridin-3-ol

반응식

[OH:1][C:2]1[CH:3]=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[N+:9]([O-])([OH:11])=[O:10]>>[OH:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 944Nitric Acid

HCID 142752-Methyl-5-hydroxypyridine

생성물 1

HCID 848016-Methyl-2-nitropyridin-3-ol

반응 조건

온도: 6 °C

실험 절차

To 40 ml. of ice cold concentrated sulfuric acid was added 10.9 g. of 3-hydroxy-6-methylpyridine. Maintaining the temperature at 6° C., 4.7 ml. of fuming nitric acid was added dropwise with stirring. The mixture was allowed to warm to room temperature overnight. Ice (200 g.) was added with stirring. After the ice had melted, the precipitate was collected, washed with water and dried to give 3-hydroxy-6-methyl-2-nitropyridine, m.p. 103°-105° C.

후처리

additionof ice cold concentrated sulfuric acid was added 10.9 g
temperatureto warm to room temperature overnight
stirringwith stirring
customthe precipitate was collected
washwashed with water
customdried

출처 및 근거

ORD 기록: ord-f3b692fa11714b5f803b8edbedaeef34
출처 데이터셋: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04131677

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