Benzoic Acid → 5-Methyl-2-phenyloxazolo[4,5-b]pyridine

HRID 66355

반응식

HRID 66355 반응식
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1.[C:10](O)(=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O.C(=O)(O)[O-].[Na+]>[CH3:9][C:4]1[N:3]=[C:2]2[N:1]=[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[O:8][C:7]2=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 243Benzoic AcidHCID 885002-Amino-6-methylpyridin-3-ol

생성물 1

HCID 199904835-Methyl-2-phenyloxazolo[4,5-b]pyridine

시약·촉매·용매 2

HCID 962Water용매HCID 516892Sodium Bicarbonate용매

실험 절차

A mixture of 1.25 g. of 2-amino-3-hydroxy-6-methylpyridine, 6 g. of polyphosphoric acid and 2.0 g. benzoic acid was heated at 190°-200° C. for 10 minutes. The cooled mixture was diluted with water and basified with solid sodium bicarbonate. The resulting precipitate was collected and recrystallized from ether to give 5-methyl-2-phenyloxazolo[4,5-b]pyridine, m.p. 148°-149° C.

후처리

  1. additionA mixture of 1.25 g
  2. customThe resulting precipitate was collected
  3. customrecrystallized from ether

출처 및 근거

ORD 기록
ord-0d9bf10312bb454daf6de91028c22df8
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04131677

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