Acetone → 2-(2-Methylsulfinylphenyl)oxazolo[4,5-b]pyridine

HRID 66357노트

반응식

HRID 66357 반응식
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:10][C:11]2[C:12]([N:17]=1)=[N:13][CH:14]=[CH:15][CH:16]=2.CC(C)=[O:20].I([O-])(=O)(=O)=O.[Na+]>O>[CH3:1][S:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:10][C:11]2[C:12]([N:17]=1)=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:20]

참가 물질

5

반응물 3

HCID 180AcetoneHCID 124613832-(2-(Methylthio)phenyl)oxazolo[4,5-b]pyridineHCID 23667635Sodium periodate

생성물 1

HCID 227547742-(2-Methylsulfinylphenyl)oxazolo[4,5-b]pyridine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 0.5 g. of 2-(2-methylthiophenyl)oxazolo[4,5-b]pyridine in 50 ml. of acetone was treated with 3 g. of sodium metaperiodate. After stirring over the weekend at room temperature, the mixture was diluted with 30 ml. of water. The acetone was distilled out and the resulting precipitate was recrystallized to give 2-(2-methylsulfinylphenyl)oxazolo[4,5-b]pyridine, m.p. 153.5°-155.5° C.

후처리

  1. additionthe mixture was diluted with 30 ml
  2. distillationThe acetone was distilled out
  3. customthe resulting precipitate was recrystallized

출처 및 근거

ORD 기록
ord-548d223cad3b4458973ef2116fdf6cae
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04131677

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