2-Fluorobenzoyl chloride → 3-(2-Fluorobenzoylamino)-2-pyridone
반응식
[NH2:1][C:2]1[C:3](=[O:8])[NH:4][CH:5]=[CH:6][CH:7]=1.[F:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](Cl)=[O:13]>N1C=CC=CC=1>[F:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:1][C:2]1[C:3](=[O:8])[NH:4][CH:5]=[CH:6][CH:7]=1)=[O:13]참가 물질
4
실험 절차
To a solution of 3.3 g. (0.03 mole) of 3-amino-2-pyridone in 75 ml. of pyridine cooled in ice was added portionwise 6.3 g. (0.04 mole) of 2-fluorobenzoyl chloride over 5 minutes. After stirring for 15 hours at ambient temperature, the mixture was poured into ice-water. The resultant precipitate was collected by filtration, washed with water and recrystallized from ethanol to give 3-(2-fluorobenzoylamino)-2-pyridone, m.p. 223° C.
후처리
- additionwas added portionwise 6.3 g
- filtrationThe resultant precipitate was collected by filtration
- washwashed with water
- customrecrystallized from ethanol
출처 및 근거
- ORD 기록
- ord-6cd5c49560994244a0d836c696125f9b
- 출처 데이터셋
- uspto-grants-1978_12
- 특허 번호
- US04131677
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