Thionyl Chloride → 3,4-Dihydro-4,4-dimethyl-2H-pyran-2-one

HRID 66455노트

반응식

HRID 66455 반응식
[CH3:1][C:2]([CH3:10])([CH2:7][CH:8]=[O:9])[CH2:3][C:4](O)=[O:5].S(Cl)(Cl)=O>C1C=CC=CC=1>[CH3:1][C:2]1([CH3:10])[CH:7]=[CH:8][O:9][C:4](=[O:5])[CH2:3]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 30187243,3-Dimethyl-5-oxopentanoic acid

생성물 1

HCID 30186853,4-Dihydro-4,4-dimethyl-2H-pyran-2-one

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of 1.05 g (7.28 mmol) of crude 3,3-dimethyl-5-oxopentanoic acid (from Example 8a) and 1 g (8.4 mmol) of thionyl chloride in 10 mL of benzene was heated under reflux for 62/3 hours. The reaction mixture was concentrated to give 3,4-dihydro-4,4-dimethyl-2H-pyran-2-one. The nmr spectrum was consistent with the proposed structure.

후처리

  1. temperatureunder reflux for 62/3 hours
  2. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-0743c860bc734091aac98b5a4aae2c8c
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04342694

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