Ethyl Acrylate → 4-Oxo-4-(thiophen-3-yl)butanoic acid

HRID 66483

반응식

HRID 66483 반응식
[S:1]1[CH:5]=[CH:4][C:3]([CH:6]=[O:7])=[CH:2]1.S1C=CC(C(N2CCOCC2)C#N)=C1.[C:22]([O:26]CC)(=[O:25])[CH:23]=[CH2:24].[OH-].[K+]>C(O)C.O1CCCC1>[CH:2]1[S:1][CH:5]=[CH:4][C:3]=1[C:6]([CH2:24][CH2:23][C:22]([OH:26])=[O:25])=[O:7]

참가 물질

7

반응물 4

HCID 8821Ethyl AcrylateHCID 14797Potassium HydroxideHCID 681353-ThiophenecarboxaldehydeHCID 130416994-Morpholinyl(3-thienyl)acetonitrile

생성물 1

HCID 3156574-Oxo-4-(thiophen-3-yl)butanoic acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

As for Example 6, 99 g. of 3-thiophenecarboxaldehyde is converted to α-(3-thienyl)-4-morpholineacetonitrile (137 g.; m.p. 85°-87° C.). The preceding compound 50.5 g. is reacted with 100 ml. of ethyl acrylate in 500 ml. of tetrahydrofuran in the presence of 50 ml. of 30% potassium hydroxide in ethanol. The solvent is removed from the reaction mixture and the residue is heated with 6 N hydrochloric acid to give 3-(3-thenoyl)propionic acid. As for Example 1, the preceding compound is converted to the product of the Example to give a glass.

후처리

  1. customis reacted with 100 ml
  2. customThe solvent is removed from the reaction mixture
  3. temperaturethe residue is heated with 6 N hydrochloric acid

출처 및 근거

ORD 기록
ord-b323d8b8969a4f969af3b89e62aa45ea
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04342689

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