Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 665생성일: 2026년 10월 23일
2-Amino-5-bromo-4-methoxypyrimidine → 5-bromo-N-[2-fluoro-5-(trifluoromethyl)phenyl]-4-methoxypyrimidin-2-amine
https://huagongshe.com/ko/reaction/665
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Amino-5-bromo-4-methoxypyrimidine | HCID 45036937 | — |
| 반응물 | 1-Fluoro-2-iodo-4-(trifluoromethyl)benzene | HCID 46735235 | — |
| 시약 | Cesium carbonate | HCID 10796 | — |
| 촉매 | Tris(furan-2-yl)phosphane | HCID 521585 | — |
| 촉매 | Palladium (II) acetate | HCID 4144353 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 5-bromo-N-[2-fluoro-5-(trifluoromethyl)phenyl]-4-methoxypyrimidin-2-amine | HCID 106998904 | 0% |
반응 단계
To a microwave vial was added a mixture of 5-bromo-4-methoxypyrimidin-2-amine (0.513 g, 2.51 mmol), diacetoxypalladium (0.055 g, 0.245 mmol), tri(furan-2-yl)phosphine (0.126 g, 0.54 mmol), 1-fluoro-2-iodo-4-(trifluoromethyl)benzene (0.98 g, 3.38 mmol) and toluene (17 mL) under inert atmosphere. The reaction mixture was sealed and heated at 90 °C under 15h. The LCMS indicated no reaction ??? The sample discarded.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-f903bfa68e6e46fb8291b98645969acd |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
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