Dichloromethane → 4-[(6-chloropyridin-3-yl)methyl]-7-hydroxy-5,6,7,7a-tetrahydrofuro-[3,2-b]pyridin-2(4H)-one

반응식

[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][N:9]([C:15](=[O:16])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:17][CH2:18][CH:19]([CH:20]2[O:21][C:22](=[O:30])[CH:23]=[C:24]2[N:10]2[CH2:11][CH2:12][CH2:13][CH2:14]2)[OH:31])[cH:6][n:7]1.[Cl:32][CH2:33][Cl:34].[OH:35][C:36]([C:37]([F:38])([F:39])[F:40])=[O:41]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][N:9]2[CH2:17][CH2:18][CH:19]([OH:31])[CH:20]3[O:21][C:22](=[O:30])[CH:23]=[C:24]23)[cH:6][n:7]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 86632443Tert-butyl [(6-chloropyridin-3-yl)methyl][3-hydroxy-3-(5-oxo-3-pyrrolidin-1-yl-2,5-dihydrofuran-2-yl)propyl]carbamate

생성물 1

HCID 577798174-[(6-chloropyridin-3-yl)methyl]-7-hydroxy-5,6,7,7a-tetrahydrofuro-[3,2-b]pyridin-2(4H)-one

출처 및 근거

ORD 기록: ord-0314fd0a1cb64359be724fc7bad6daf9
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

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