2-(4-Chlorophenyl)ethylamine → HCID 178512614, 화합물

HRID 66578

반응식

HRID 66578 반응식
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH:10]2[CH2:15][CH2:14][CH2:13][CH:12]([NH:16][C:17]3[C:20](=O)[C:19](=[O:22])[C:18]=3[O:23]C)[CH2:11]2)[N:9]=1)[C:2]([NH2:4])=[NH:3].[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][NH2:34])=[CH:28][CH:27]=1>CO.C(Cl)(Cl)Cl>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH:10]2[CH2:15][CH2:14][CH2:13][CH:12]([NH:16][C:17]3[C:18](=[O:23])[C:19](=[O:22])[C:20]=3[NH:34][CH2:33][CH2:32][C:29]3[CH:30]=[CH:31][C:26]([Cl:25])=[CH:27][CH:28]=3)[CH2:11]2)[N:9]=1)[C:2]([NH2:4])=[NH:3]

참가 물질

4

반응물 2

HCID 674302-(4-Chlorophenyl)ethylamineHCID 178493670HCID 178493670, 화합물

생성물 1

HCID 178512614HCID 178512614, 화합물

시약·촉매·용매 1

HCID 21584188Chloroform methanol용매

실험 절차

To a solution of 1-[3-(2-guanidinothiazol-4-yl)cyclohexylamino]-2-methoxycyclobutene-3,4-dione (0.19 g.) in 35 ml. of methanol/chloroform (50:50 v/v) was added 2-(p-chlorophenyl)ethylamine (0.18 g.) and the resulting mixture allowed to stand at room temperature for 5 hours. After heating under reflux for 2.5 hours the reaction mixture was cooled and the precipitated buff-coloured solid collected to give 1-[3-(2-guanidinothiazol-4-yl)cyclohexylamino]-2-[2-(p-chlorophenyl)ethylamino]cyclobutene-3,4-dione. The n.m.r. spectrum in d6 dimethylsulphoxide included resonances at 1.2 (m), 1.8 (m), 2.5 (t), 3.7 (m), 6.24 (s), 6.78 (br s).

후처리

  1. temperatureAfter heating
  2. temperatureunder reflux for 2.5 hours the reaction mixture
  3. temperaturewas cooled
  4. customthe precipitated buff-coloured solid collected

출처 및 근거

ORD 기록
ord-4317b11e0d0c4be0b00fb8b6f1b315db
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04342765

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