Alloxan → 5-Hydroxy-5-(2-benzthiazolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione

반응식

[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[NH:10]1[C:18](=[O:19])[C:16](=[O:17])[C:14](=[O:15])[NH:13][C:11]1=[O:12]>>[OH:17][C:16]1([C:2]2[S:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=2)[C:14](=[O:15])[NH:13][C:11](=[O:12])[NH:10][C:18]1=[O:19]

참가 물질

반응물 2

HCID 5781Alloxan

HCID 7222Benzothiazole

생성물 1

HCID 212712615-Hydroxy-5-(2-benzthiazolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione

실험 절차

By the procedure of Example 38, benzthiazole (2.7 g., 0.02 moles) was converted to its 2-lithio derivative and then reacted with anhydrous alloxan to yield title product, initially isolated as an oil. The latter was crystallized from ether-hexane [2.2 g.; Rf 0.55 (1:1 ethyl acetate:hexane/5% acetic acid)].

출처 및 근거

ORD 기록: ord-b64932bbb0184341ae473f55d33fce7e
출처 데이터셋: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04342771

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