Decylamine → N-Decyl-3-phenyl-3-(4-nitrophenyl)propenamide

HRID 66618

반응식

HRID 66618 반응식
[CH2:1]([NH2:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[C:12]1([C:18]([C:23]2[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=2)=[CH:19][C:20](Cl)=[O:21])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>O1CCCC1>[CH2:1]([NH:11][C:20](=[O:21])[CH:19]=[C:18]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:23]1[CH:24]=[CH:25][C:26]([N+:29]([O-:31])=[O:30])=[CH:27][CH:28]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

참가 물질

4

반응물 2

HCID 8916DecylamineHCID 545299323-Phenyl-3-(4-nitrophenyl)propenoyl chloride

생성물 1

HCID 53643429N-Decyl-3-phenyl-3-(4-nitrophenyl)propenamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a stirred solution of 5.89 g. of decylamine in 25 ml. of tetrahydrofuran was added a solution of 4.89 g. of 3-phenyl-3-(4-nitrophenyl)propenoyl chloride in 25 ml. of tetrahydrofuran, dropwise, during 20 minutes, at ice-bath temperature. The solvent was removed by evaporation in vacuo and the residue was partitioned between ethyl acetate and water. The layers were separated, and the ethyl acetate layer was washed with water, dried using sodium sulfate, and then evaporated in vacuo. This afforded 5.6 g. of the title compound, m.p. 91°-93° C.

후처리

  1. customThe solvent was removed by evaporation in vacuo
  2. customthe residue was partitioned between ethyl acetate and water
  3. customThe layers were separated
  4. washthe ethyl acetate layer was washed with water
  5. customdried
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-95afdeb0788641779bcbb9277debbf05
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04342781

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