Potassium Carbonate → HCID 178432777, 화합물

HRID 66720

반응식

HRID 66720 반응식
[Cl:1][C:2]([Cl:7])([Cl:6])[C:3]([NH2:5])=[NH:4].C(=O)([O-])[O-].[K+].[K+].[Cl:14][CH:15]([C:21]([CH3:23])=O)[C:16](OCC)=[O:17]>O>[Cl:14][C:15]1[C:16]([OH:17])=[N:4][C:3]([C:2]([Cl:7])([Cl:6])[Cl:1])=[N:5][C:21]=1[CH3:23]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 11858Ethyl 2-chloroacetoacetateHCID 356082,2,2-Trichloroethanimidamide

생성물 1

HCID 178432777HCID 178432777, 화합물수율 31%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 30.0 g (0.18 mole) trichloroacetamidine, 25.2 g (0.18 mole) potassium carbonate, 30.3 g (0.18 mole) ethyl 2-chloroacetoacetate, and 300 ml water was stirred 18 hours. The aqueous solution was decanted from heavier tars and acidified with hydrochloric acid. The precipitate that was formed was filtered, washed, and dried to give 14.7 g (31% yield; mp 130°-145° C.) of crude product. An analytical sample recrystallized from cyclohexane had mp 156°-157° C. The structure was confirmed via infrared and elemental analysis.

후처리

  1. customThe aqueous solution was decanted from heavier tars
  2. customThe precipitate that was formed
  3. filtrationwas filtered
  4. washwashed
  5. customdried
  6. customto give 14.7 g (31% yield; mp 130°-145° C.) of crude product
  7. customAn analytical sample recrystallized from cyclohexane

출처 및 근거

ORD 기록
ord-7fa793f8618c41de8b007b91799daca8
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343803

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